Innate immune responses to Listeria in vivo

Listeria monocytogenes (Lm) is a foodborne bacterial pathogen that causes listeriosis, severe infection manifests as bacteremia and meningo-encephalitis mostly in immunocompromised individuals, maternal–fetal infection. A critical pathogenic determinant of Lm relies on its ability to actively cross the intestinal barrier, disseminate systemically blood–brain placental barriers. Here we illustrate how both evades innate immunity, favoring dissemination host tissues, triggers immune defenses participate control.